Endocrine Abstracts

Background: Endocrinology is well-established as an outpatient specialty. However, virtually no data exist on the volume, nature, management and disposal of inpatient referrals to inform the design and delivery of a quality-assured service.Methods: We undertook an audit of all activity of the Inpatient Endocrine Service at University Hospitals Birmingham NHSFT (IES@UHB) between January 2010 and December 2015. Referrals received electronically via the Pat...

Introduction: Spontaneous fertility in Turner syndrome (TS) is rare, due to low or absent ovarian reserve. A greater number of ovarian follicules is present in the cases of gonadal mosaicism, although the accelerated pace of apoptosis remains. Thus, the early referral to reproductive counseling is advisable, ideally soon after diagnosis. The criopreservation of oocytes is one of the options for fertility preservation. The authors present a series of 7 patients with TS admitted...

Introduction: Bilateral adrenalectomy (BADx) is a treatment option in ACTH-dependent Cushing’s syndrome refractory to other therapeutic modalities or can be an emergency measure in cases with severe manifestations of hypercortisolaemia.Aim: To review the outcomes of our patients with ACTH-dependent Cushing’s offered BADx.Methods: Records of patients with ACTH-dependent Cushing’s managed by BADx and seen in our Depart...

Background: Transition is an important stage in the care of a young person with a long term endocrine condition.Objective: To explore current services for young people (YP) with endocrine conditions from the perspective of paediatric and adult endocrinologists, and YP and their parents using their services.Methods: There were two components: i) service questionnaire for completion by paediatric and adult endocrinologists. ii) &#145...

Introduction: The need to fast for the determination of lipid profile has been discussed in the past years, for several reasons – i) most of the day time is spent in a postprandial state; ii) the lipid concentrations seem to be only slightly affected by a normal meal; both fasting and postprandial can predict cardiovascular risk.Aim: Determine the influence of normal food intake on the lipid profile of diabetic patients.Method...

Background and aim: Low T3 syndrome is associated with a poor prognosis in patients with chronic heart failure (CHF). It is controversial whether T3 treatment is indicated in CHF. A previous study using intravenous infusion of T3 for 72 h suggested a beneficial effect on cardiac performance.We aimed to evaluate the effect of 13 weeks of T3 treatment in patients with stable CHF on left ventricular ejection fraction (LVEF) compared to placebo.<p class=...

Introduction: It is known that type 2 diabetes increases the risk of cardiovascular disease. Fetuin-A is a multifunctional serum glycoprotein and its role in the pathogenesis of type 2 diabetes, atherosclerosis and cardiovascular disease is still discussed.Material and methods: The study was conducted in 36 patients (12 F and 24 M) with type 2 diabetes mellitus (DM2) and acute coronary syndrome (ACS), aged mean 70.22±7.62. The group was divided into...

Introduction: It’s known that type 2 diabetes increases the risk of cardiovascular disease. Silent myocardial ischemia occurs frequently in diabetics and may result in more severe coronary artery disease. Osteoprotegerin (OPG) is a glycoprotein secreted mainly by osteoblasts but it’s also produced by heart muscle. Its role in the pathogenesis of type 2 diabetes, atherosclerosis and future cardiovascular events is still discussed.Material and me...

Background: Currently little data regarding hypothyroidism in South Africa exists, but it can be seen from international literature that a significant amount of patients, fail to reach target TSH levels.Objectives: This observational study aimed to measure the efficacy of individually titrated doses of levothyroxine to achieve a euthyroid state.Methods: Patients with hypothyroidism, treatment naïve and insufficiently controlle...

Hyponatremia is a common disorder, especially among the elderly, and an important morbidity and mortality cause. Empty sella syndrome, on the other hand, is a rare entity, more common in women between their fourth and sixth decade of life, and endocrine dysfunction has been reported in 10–60% of the cases. A 68-year-old man, with a past medical history of essential hypertension and glaucoma, presented at the emergency room due to malaise, asthenia, somnolence and anorexi...